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Archives of Pathology & Laboratory... Jan 2004Epithelial-myoepithelial tumor is extremely rare as a pulmonary neoplasm. Only 20 cases have been reported to date, of which 14 were malignant. We report a case of... (Review)
Review
Epithelial-myoepithelial tumor is extremely rare as a pulmonary neoplasm. Only 20 cases have been reported to date, of which 14 were malignant. We report a case of intrabronchial epithelial-myoepithelial carcinoma in a 73-year-old man with a history of heavy smoking. The tumor was well-circumscribed and caused distal airway obstruction. Histologically, the tumor showed glandular and solid architecture. The glands were composed of an inner layer of epithelial cells and an outer layer of myoepithelial cells. The solid areas consisted of spindle-shaped myoepithelial cells. Immunohistochemical staining was positive for p53 and c-Kit (CD117). Focal atypia and increased mitotic activity were present, but no vascular invasion or nodal metastasis was identified.
Topics: Aged; Carcinoma; Carcinoma, Bronchogenic; Humans; Male; Myoepithelioma; Tomography, X-Ray Computed
PubMed: 14692803
DOI: 10.5858/2004-128-92-BEC -
Journal of Thoracic Oncology : Official... Nov 2009Carinal resection and reconstruction is technically demanding. The aim of this study is to discuss the clinical value of carinoplasty in the surgical treatment of... (Comparative Study)
Comparative Study
BACKGROUND
Carinal resection and reconstruction is technically demanding. The aim of this study is to discuss the clinical value of carinoplasty in the surgical treatment of bronchogenic carcinoma involving carina.
MATERIALS AND METHODS
From 1982 to 2006, 41 cases of centrally placed bronchogenic carcinoma invading the carina were treated with carinal resection and reconstruction in our hospital. Among the 41 patients, 25 patients simultaneously underwent additional cardiovascular plasty operations besides carinoplasty. There were 12 different types of carinal resection and reconstruction in our group.
RESULTS
In this group, there was one perioperative death due to anastomotic leakage. This patient died 2 weeks postoperatively. Arrhythmia occurred in 12 patients, atelectasis in eight patients, and pneumonia in five patients. Five patients had to be assisted with mechanical ventilation because of pulmonary function failure. Anastomosis stenoses were found in three patients 3 to 6 months postoperatively and were resolved by stent insertion. Thirty-one patients were diagnosed with tumor recurrences after operations. Progression-free survival was 75.6% at 1 year, 43.9% at 3 years, and 22.0% at 5 years; the overall actuarial survival was 75.6% at 1 year, 46.3% at 3 years, and 26.8% at 5 years. Survival was better in patients with N0-1 disease than those with N2 disease (37.0% versus 7.1% at 5 years).
CONCLUSION
Carinoplasty for bronchogenic carcinoma involving carina is feasible with acceptable morbidity and mortality if patients are selected carefully. Preoperative evaluation of the mediastinum is crucial for treatment selection.
Topics: Adult; Aged; Anastomosis, Surgical; Carcinoma, Bronchogenic; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Plastic Surgery Procedures; Retrospective Studies; Time Factors; Trachea; Tracheal Neoplasms; Treatment Outcome
PubMed: 19745770
DOI: 10.1097/JTO.0b013e3181b9ca8e -
Journal of Cancer Research and... 2009This study was undertaken to explore the clinicopathological profile of bronchogenic carcinoma in young patients. (Comparative Study)
Comparative Study
OBJECTIVE
This study was undertaken to explore the clinicopathological profile of bronchogenic carcinoma in young patients.
MATERIALS AND METHODS
The present study was conducted on 799 consecutive histopathologically proven cases of bronchogenic carcinoma that were referred from different parts of Uttar Pradesh.
RESULTS
Out of 799 patients, 73 patients (9.1%; 59 males and 14 females) were < or = 40 years of age and were classified as 'young' patients. The mean ages of the subjects in the younger and older patient groups were 36 and 58 years, respectively. Among the older patients, 590 (81.3%) were smokers, and there were 53 (72.6%) smokers among the younger patients. Squamous cell carcinoma was the commonest histological subtype in both the groups, but squamous cell carcinoma was more frequently diagnosed in older patients than in younger patients.
CONCLUSION
This study suggests that, regardless of age or sex, lung cancer must be ruled out in all patients who have persistent signs of pulmonary disease and a history of heavy smoking.
Topics: Adult; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Smoking
PubMed: 19293486
DOI: 10.4103/0973-1482.44296 -
Revista Espanola de Salud Publica Jun 2023Bronchogenic carcinoma (BC) is the second most frequent worldwide and the most lethal tumour in both sexes. Its incidence varies not only among countries but also among... (Observational Study)
Observational Study
OBJECTIVE
Bronchogenic carcinoma (BC) is the second most frequent worldwide and the most lethal tumour in both sexes. Its incidence varies not only among countries but also among different areas of the same country. So, the aim of this work was to analyse the evolution of its incidence and survival in the province of Castellón from 2004 to 2017 and to compare them with those of de rest of the country.
METHODS
A retrospective observational study was carried out from patients diagnosed with BC and registered in the Castellón Tumour Register from 2004 to 2017. Survival was estimated using the Kaplan-Meier method whereas to estimate the relationship among different variables both the chi-square and ANOVA test were used.
RESULTS
4,346 cases were diagnosed, whose mean age was 67.5±11.3 years, 85.2% men, the most frequent histological types were adenocarcinoma (28.3%) and epidermoid carcinoma (25.1%). The gross global incidence was 53.4 cases/105 inhabitants, 90.9 cases/105 men and 15.7 cases/105 women. Median global survival at five years was 12.7%, 12% in men and 18.4% in women.
CONCLUSIONS
The global incidence of BC in Castellón is lower than the national one, having remained stable in men while it is double in women. Global survival at five years is less than 15%, being higher in women than in men, nevertheless it increases compared to that of previous studies.
Topics: Male; Humans; Female; Middle Aged; Aged; Lung Neoplasms; Spain; Incidence; Carcinoma, Bronchogenic; Retrospective Studies
PubMed: 37325902
DOI: No ID Found -
Asian Pacific Journal of Cancer... Dec 2018Background: Bronchogenic carcinoma (lung cancer) is one of the leading causes of death. Although many compounds isolated from natural products have been used to treat...
Melittin Induced G1 Cell Cycle Arrest and Apoptosis in Chago-K1 Human Bronchogenic Carcinoma Cells and Inhibited the Differentiation of THP-1 Cells into Tumour- Associated Macrophages.
Background: Bronchogenic carcinoma (lung cancer) is one of the leading causes of death. Although many compounds isolated from natural products have been used to treat it, drug resistance is a serious problem, and alternative anti-cancer drugs are required. Here, melittin from Apis mellifera venom was used, and its effects on bronchogenic carcinoma cell proliferation and tumour-associated macrophage differentiation were evaluated. Methods: The half maximal inhibitory concentration (IC50) of melittin was measured by MTT. Cell death was observed by annexin V and propidium iodide (PI) co-staining followed by flow cytometry. Cell cycle arrest was revealed by PI staining and flow cytometry. To investigate the tumour microenvironment, differentiation of circulating monocytes (THP-1) into tumour-associated macrophages (TAMs) was assayed by sandwich-ELISA and interleukin (IL)-10 levels were determined. Cell proliferation and migration was observed by flat plate colony formation. Secretion of vascular endothelial growth factor (VEGF) was detected by ELISA. The change in expression levels of CatS, Bcl-2, and MADD was measured by quantitative RT-PCR. Results: Melittin was significantly more cytotoxic (p < 0.01) to human bronchogenic carcinoma cells (ChaGo-K1) than to the control human lung fibroblasts (Wi-38) cells. At 2.5 μM, melittin caused ChaGo-K1 cells to undergo apoptosis and cell cycle arrest at the G1 phase. The IL-10 levels showed that melittin significantly inhibited the differentiation of THP-1 cells into TAMs (p < 0.05) and reduced the number of colonies formed in the treated ChaGo-K1 cells compared to the untreated cells. However, melittin did not affect angiogenesis in ChaGo-K1 cells. Unlike MADD, Bcl-2 was up-regulated significantly (p < 0.05) in melittin-treated ChaGo-K1 cells. Conclusion: Melittin can be used as an alternative agent for lung cancer treatment because of its cytotoxicity against ChaGo-K1 cells and the inhibition of differentiation of THP-1 cells into TAMs.
Topics: Apoptosis; Carcinoma, Bronchogenic; Carrier Proteins; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Death Domain Receptor Signaling Adaptor Proteins; G1 Phase; Humans; Interleukin-10; Macrophages; Melitten; Monocytes; Proto-Oncogene Proteins c-bcl-2; THP-1 Cells; Vascular Endothelial Growth Factor A
PubMed: 30583665
DOI: 10.31557/APJCP.2018.19.12.3427 -
Journal of Thoracic Oncology : Official... Dec 2008Lung cancer may occur in the lung transplant population because many patients are former smokers. Not much is known about risk factors and outcomes in these patients.
BACKGROUND
Lung cancer may occur in the lung transplant population because many patients are former smokers. Not much is known about risk factors and outcomes in these patients.
METHODS
We performed a search of the lung transplant database at our institution to identify patients who had been diagnosed with lung cancer. Records and reports were reviewed for demographics, risk factors for malignancy, lung transplant characteristics, radiographic characteristics, treatment, and outcomes.
RESULTS
We identified 12 lung transplant patients with bronchogenic carcinoma at our institution [age 47.2 +/- 13.2 years (mean +/- SD); 7 (58%) men and 5 (42%) women]. Eleven patients were transplanted for chronic obstructive pulmonary disease (COPD). Time from transplantation to diagnosis of cancer was 119 (21-416) [mean (range)] weeks. Eleven cancers occurred in the native lung; most common cancer cell types were adenocarcinoma (N = 5). Incidence among patients with COPD, who received single lung transplantation was 5.15%. Time from diagnosis of bronchogenic carcinoma to death was 10.8 (1-60) [mean (range)] weeks with a 75% (9/12) 1-year mortality.
CONCLUSIONS
Among our patients, almost all cancers occurred in native lung in ex-smokers who received a lung transplant for COPD. The cancer was often an incidental finding on a routine chest radiograph; however, the disease was usually at an advanced stage at diagnosis, limiting therapeutic options.
Topics: Adult; Aged; Carcinoma, Bronchogenic; Female; Follow-Up Studies; Humans; Incidence; Lung Neoplasms; Lung Transplantation; Male; Middle Aged; Neoplasm Recurrence, Local; Pulmonary Disease, Chronic Obstructive; Risk Factors; Treatment Outcome
PubMed: 19057264
DOI: 10.1097/JTO.0b013e31818e1259 -
Korean Journal of Radiology 2001Bronchogenic carcinoma can mimic or be masked by pulmonary tuberculosis (TB), and the aim of this study was to describe the radiologic findings and clinical significance...
OBJECTIVE
Bronchogenic carcinoma can mimic or be masked by pulmonary tuberculosis (TB), and the aim of this study was to describe the radiologic findings and clinical significance of bronchogenic carcinoma and pulmonary TB which coexist in the same lobe.
MATERIALS AND METHODS
The findings of 51 patients (48 males and three females, aged 48-79 years) in whom pulmonary TB and bronchogenic carcinoma coexisted in the same lobe were analyzed. The morphologic characteristics of a tumor, such as its diameter and margin, the presence of calcification or cavitation, and mediastinal lymphadenopathy, as seen at CT, were retrospectively assessed, and the clinical stage of the lung cancer was also determined. Using the serial chest radiographs available for 21 patients, the possible causes of delay in the diagnosis of lung cancer were analyzed.
RESULTS
Lung cancers with coexisting pulmonary TB were located predominantly in the upper lobes (82.4%). The mean diameter of the mass was 5.3 cm, and most tumors (n=42, 82.4%) had a lobulated border. Calcification within the tumor was seen in 20 patients (39.2%), and cavitation in five (9.8%). Forty-two (82.4%) had mediastinal lymphadenopathy, and more than half the tumors (60.8%) were at an advanced stage [IIIB (n=11) or IV (n=20)]. The average delay in diagnosing lung cancer was 11.7 (range, 1-24) months, and the causes of this were failure to observe new nodules masked by coexisting stable TB lesions (n=8), misinterpretation of new lesions as aggravation of TB (n=5), misinterpretation of lung cancer as tuberculoma at initial radiography (n=4), masking of the nodule by an active TB lesion (n=3), and subtleness of the lesion (n=1).
CONCLUSION
Most cancers concurrent with TB are large, lobulated masses with mediastinal lymphadenopathy, indicating that the morphologic characteristics of lung cancer with coexisting pulmonary TB are similar to those of lung cancer without TB. The diagnosis of lung cancer is delayed mainly because of masking by a tuberculous lesion, and this suggests that in patients in whom a predominant or growing nodule is present and who show little improvement of symptoms despite antituberculous or other medical therapy, coexisting cancer should be suspected.
Topics: Aged; Carcinoma, Bronchogenic; Female; Humans; Lung Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed; Tuberculosis, Pulmonary
PubMed: 11752984
DOI: 10.3348/kjr.2001.2.3.138 -
Annals of Surgery Jan 1955
Topics: Carcinoma, Bronchogenic; Humans; Lung Neoplasms
PubMed: 13218543
DOI: 10.1097/00000658-195501000-00010 -
Jornal Brasileiro de Pneumologia :... Apr 2022
Topics: Bronchial Neoplasms; COVID-19; Carcinoma, Bronchogenic; Histoplasmosis; Humans; Pandemics
PubMed: 35475862
DOI: 10.36416/1806-3756/e20210048 -
Cancer Reports (Hoboken, N.J.) Aug 2021Metastatic disease to the eye most commonly involves choroid followed by orbit leading to varied ocular manifestations. By comparison, it is relatively rarer than...
BACKGROUND
Metastatic disease to the eye most commonly involves choroid followed by orbit leading to varied ocular manifestations. By comparison, it is relatively rarer than primary malignancies of eye as well as metastasis in other parts of the body.
AIM
The aim of this study is to evaluate the common eye and orbital structures involved in secondary ocular and metastatic disease, to describe its clinical manifestations and outline the management done.
METHODS
A retrospective study of newly diagnosed cases of ocular metastasis in last 2 years conducted in our recently established department of ocular oncology at a tertiary eye care hospital in Nepal. Demography, age and sex distribution were noted. The patients were segregated into those with secondary or metastatic ocular malignancies. Detail study on the metastatic disease to eye was made in regards to presenting symptoms, signs, primary site of cancer, and the treatment done. Details of the investigations done, like biopsy and imaging were also recorded.
RESULTS
There were a total of 28 patients, whose age group ranged from 9 years to 69 years with median age of 43 years. Females constituted 46% of total patients. Both the eyes were involved in 9 patients (32%). Eye was secondarily involved by paranasal sinus tumors and Non Hodgkin lymphoma (7 patients each). Ocular metastasis was commonly seen from broncogenic carcinoma in four and breast carcinoma in three patients. Simultaneous metastasis to other parts of the body was also seen in 61% of our patients. Diminution of vision in 49% was the most common presenting feature followed by proptosis in 16% and palpable mass in 14% of patients. Orbit in 43% cases is the commonest ocular structure involved. Histopathologic diagnosis was done in 32% only while rest was based on imaging alone. The most common treatment done was chemotherapy in 57% patients.
CONCLUSION
Ocular metastasis can display a wide variety of clinical and imaging features and therefore a high degree of suspicion is required. It is often associated with simultaneous metastasis to other parts of the body as well, hence the importance of earlier diagnosis and metastatic workup.
Topics: Adolescent; Adult; Aged; Carcinoma, Bronchogenic; Child; Eye Neoplasms; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nepal; Orbital Neoplasms; Paranasal Sinus Neoplasms; Retrospective Studies; Young Adult
PubMed: 33535273
DOI: 10.1002/cnr2.1347